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Tramadol medication is used to prevent and treat moderate to severe pain. This medicine can also be used to treat other conditions as determined by your doctor. It works by blocking the reuptake of certain natural substances in your brain, spinal cord, and nerves. Tramadol may be taken with food or on an empty stomach. It may take up to 4 hours for the effects of the medicine to fully kick in, so you should not drive or perform any hazardous tasks if you take tramadol for pain relief.